The EP_Airflow component models ventilation air flow rate as function of wind speed, and stack-effect, or an input design flow rate. So it isn’t simulating a pressure difference to calculate ventilation rates. For that you need the EnergyPlus methods from the Airflow Network Group, which hasn’t been integrated in Honeybee yet. As such, it doesn’t take wind pressure coefficients as an input.
If you have wind pressure coefficients from a uniquely sheltered site, and want to understand the ventilation impact then at least one of these methods, the wind and stack ventilation method via the EnergyPlus’ Airflow Group won’t work. It’s based on the vector sum of the volumetric flow of local wind speed, and stack effect velocity, at your zone height. So rather then wind pressure, that aspect of flow rate is approximated from the wind speed and direction, derived from the wind speeds at the airport station, and can only account for changes in height and direction of wind - not local geometry. If that’s all you’re looking to account for, it’ll work, but not if you’re looking approximate complex local site conditions.
However, there is also the design flow rate method (which HB does have). I’m only speculating here, but I wonder if you can find a way to generate a list of design flow rates (i.e flow/area, ACH) using your wind pressure coefficients, then perhaps you can account for local conditions reflected in your wind pressure coefficients. I’m thinking specifically of what some of the Butterfly users were suggesting here: Wind pressure on facade to calculate infiltration rate - Another potential way to link Butterfly to Honeybee.